Surface Modification of Gold Nanoparticles to Improve Cancer Cell Targeting
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Gold Nanoparticles, Nanoparticle Stability, Surface Modification
Abstract
Gold nanoparticles (AuNPs) are promising agents for cancer therapy due to their unique properties, but effective targeting remains a challenge. Surface modification with specific ligands can enhance targeting efficiency. To develop and optimize surface-modified AuNPs to improve targeting of cancer cells, enhancing therapeutic outcomes while minimizing side effects. The study employed theoretical modeling, laboratory experiments, and in vivo testing. Cancer cell lines (MCF-7, A549, PC-3) and mouse models with human tumors were used to evaluate targeting efficiency. Instruments included TEM, SEM, DLS, zeta potential analysis, and HPLC. Surface-modified AuNPs showed an 80% increase in cancer cell binding compared to unmodified AuNPs. In vivo studies demonstrated a 70% reduction in tumor volume in treated mice. Stability tests indicated consistent performance under various biological conditions. Surface modification of AuNPs with specific ligands significantly enhances their targeting ability and therapeutic efficacy against cancer cells. Further clinical trials are necessary to validate these findings for clinical application.
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References
Alle, M., G, B. R., Kim, T. H., Park, S. H., Lee, S.-H., & Kim, J.-C. (2020). Doxorubicin-carboxymethyl xanthan gum capped gold nanoparticles: Microwave synthesis, characterization, and anti-cancer activity. Carbohydrate Polymers, 229, 115511. https://doi.org/10.1016/j.carbpol.2019.115511
Badeggi, U., Ismail, E., Adeloye, A., Botha, S., Badmus, J., Marnewick, J., Cupido, C., & Hussein, A. (2020). Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents. Biomolecules, 10(3), 452. https://doi.org/10.3390/biom10030452
Bouché, M., Hsu, J. C., Dong, Y. C., Kim, J., Taing, K., & Cormode, D. P. (2020). Recent Advances in Molecular Imaging with Gold Nanoparticles. Bioconjugate Chemistry, 31(2), 303–314. https://doi.org/10.1021/acs.bioconjchem.9b00669
Cao, Y., Wu, J., Pang, B., Zhang, H., & Le, X. C. (2021). CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2. Chemical Communications, 57(56), 6871–6874. https://doi.org/10.1039/D1CC02546E
Chen, J., Gong, M., Fan, Y., Feng, J., Han, L., Xin, H. L., Cao, M., Zhang, Q., Zhang, D., Lei, D., & Yin, Y. (2022). Collective Plasmon Coupling in Gold Nanoparticle Clusters for Highly Efficient Photothermal Therapy. ACS Nano, 16(1), 910–920. https://doi.org/10.1021/acsnano.1c08485
Chen, J., Ma, Y., Du, W., Dai, T., Wang, Y., Jiang, W., Wan, Y., Wang, Y., Liang, G., & Wang, G. (2020). Furin?Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy. Advanced Functional Materials, 30(50), 2001566. https://doi.org/10.1002/adfm.202001566
Cho, N. H., Byun, G. H., Lim, Y.-C., Im, S. W., Kim, H., Lee, H.-E., Ahn, H.-Y., & Nam, K. T. (2020). Uniform Chiral Gap Synthesis for High Dissymmetry Factor in Single Plasmonic Gold Nanoparticle. ACS Nano, 14(3), 3595–3602. https://doi.org/10.1021/acsnano.9b10094
Ding, Y., Xu, H., Xu, C., Tong, Z., Zhang, S., Bai, Y., Chen, Y., Xu, Q., Zhou, L., Ding, H., Sun, Z., Yan, S., Mao, Z., & Wang, W. (2020). A Nanomedicine Fabricated from Gold Nanoparticles?Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy. Advanced Science, 7(17), 2001060. https://doi.org/10.1002/advs.202001060
Fan, J., Cheng, Y., & Sun, M. (2020). Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications. The Chemical Record, 20(12), 1474–1504. https://doi.org/10.1002/tcr.202000087
Gao, X., Liu, J., Li, M., Guo, C., Long, H., Zhang, Y., & Xin, L. (2020). Mechanistic study of selective adsorption and reduction of Au (III) to gold nanoparticles by ion-imprinted porous alginate microspheres. Chemical Engineering Journal, 385, 123897. https://doi.org/10.1016/j.cej.2019.123897
Grys, D.-B., De Nijs, B., Salmon, A. R., Huang, J., Wang, W., Chen, W.-H., Scherman, O. A., & Baumberg, J. J. (2020). Citrate Coordination and Bridging of Gold Nanoparticles: The Role of Gold Adatoms in AuNP Aging. ACS Nano, 14(7), 8689–8696. https://doi.org/10.1021/acsnano.0c03050
Gupta, N., & Malviya, R. (2021). Understanding and advancement in gold nanoparticle targeted photothermal therapy of cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1875(2), 188532. https://doi.org/10.1016/j.bbcan.2021.188532
He, X., Dai, L., Ye, L., Sun, X., Enoch, O., Hu, R., Zan, X., Lin, F., & Shen, J. (2022). A Vehicle?Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing. Advanced Science, 9(14), 2105223. https://doi.org/10.1002/advs.202105223
Hosny, M., Eltaweil, A. S., Mostafa, M., El-Badry, Y. A., Hussein, E. E., Omer, A. M., & Fawzy, M. (2022). Facile Synthesis of Gold Nanoparticles for Anticancer, Antioxidant Applications, and Photocatalytic Degradation of Toxic Organic Pollutants. ACS Omega, 7(3), 3121–3133. https://doi.org/10.1021/acsomega.1c06714
Hua, Z., Yu, T., Liu, D., & Xianyu, Y. (2021). Recent advances in gold nanoparticles-based biosensors for food safety detection. Biosensors and Bioelectronics, 179, 113076. https://doi.org/10.1016/j.bios.2021.113076
Huang, C., Wen, T., Shi, F.-J., Zeng, X.-Y., & Jiao, Y.-J. (2020a). Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay. ACS Omega, 5(21), 12550–12556. https://doi.org/10.1021/acsomega.0c01554
Huang, C., Wen, T., Shi, F.-J., Zeng, X.-Y., & Jiao, Y.-J. (2020b). Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay. ACS Omega, 5(21), 12550–12556. https://doi.org/10.1021/acsomega.0c01554
Ishida, T., Murayama, T., Taketoshi, A., & Haruta, M. (2020). Importance of Size and Contact Structure of Gold Nanoparticles for the Genesis of Unique Catalytic Processes. Chemical Reviews, 120(2), 464–525. https://doi.org/10.1021/acs.chemrev.9b00551
Khan, S. A., Shahid, S., & Lee, C.-S. (2020). Green Synthesis of Gold and Silver Nanoparticles Using Leaf Extract of Clerodendrum inerme; Characterization, Antimicrobial, and Antioxidant Activities. Biomolecules, 10(6), 835. https://doi.org/10.3390/biom10060835
Lee, T., Mohammadniaei, M., Zhang, H., Yoon, J., Choi, H. K., Guo, S., Guo, P., & Choi, J. (2020). Single Functionalized pRNA/Gold Nanoparticle for Ultrasensitive MicroRNA Detection Using Electrochemical Surface?Enhanced Raman Spectroscopy. Advanced Science, 7(3), 1902477. https://doi.org/10.1002/advs.201902477
Lew, T. T. S., Aung, K. M. M., Ow, S. Y., Amrun, S. N., Sutarlie, L., Ng, L. F. P., & Su, X. (2021). Epitope-Functionalized Gold Nanoparticles for Rapid and Selective Detection of SARS-CoV-2 IgG Antibodies. ACS Nano, 15(7), 12286–12297. https://doi.org/10.1021/acsnano.1c04091
Luo, D., Wang, X., Burda, C., & Basilion, J. P. (2021). Recent Development of Gold Nanoparticles as Contrast Agents for Cancer Diagnosis. Cancers, 13(8), 1825. https://doi.org/10.3390/cancers13081825
Mohammadniaei, M., Koyappayil, A., Sun, Y., Min, J., & Lee, M.-H. (2020). Gold nanoparticle/MXene for multiple and sensitive detection of oncomiRs based on synergetic signal amplification. Biosensors and Bioelectronics, 159, 112208. https://doi.org/10.1016/j.bios.2020.112208
Mostafavi, E., Zarepour, A., Barabadi, H., Zarrabi, A., Truong, L. B., & Medina-Cruz, D. (2022). Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic. Biotechnology Reports, 34, e00714. https://doi.org/10.1016/j.btre.2022.e00714
Oishi, M., & Saito, K. (2020). Simple Single-Legged DNA Walkers at Diffusion-Limited Nanointerfaces of Gold Nanoparticles Driven by a DNA Circuit Mechanism. ACS Nano, 14(3), 3477–3489. https://doi.org/10.1021/acsnano.9b09581
Patil, S. J., Dubal, D. P., & Lee, D.-W. (2020). Gold nanoparticles decorated rGO-ZnCo2O4 nanocomposite: A promising positive electrode for high performance hybrid supercapacitors. Chemical Engineering Journal, 379, 122211. https://doi.org/10.1016/j.cej.2019.122211
Penninckx, S., Heuskin, A.-C., Michiels, C., & Lucas, S. (2020). Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient. Cancers, 12(8), 2021. https://doi.org/10.3390/cancers12082021
Perveen, K., Husain, F. M., Qais, F. A., Khan, A., Razak, S., Afsar, T., Alam, P., Almajwal, A. M., & Abulmeaty, M. M. A. (2021). Microwave-Assisted Rapid Green Synthesis of Gold Nanoparticles Using Seed Extract of Trachyspermum ammi: ROS Mediated Biofilm Inhibition and Anticancer Activity. Biomolecules, 11(2), 197. https://doi.org/10.3390/biom11020197
Qian, J., Ren, C., Wang, C., An, K., Cui, H., Hao, N., & Wang, K. (2020). Gold nanoparticles mediated designing of versatile aptasensor for colorimetric/electrochemical dual-channel detection of aflatoxin B1. Biosensors and Bioelectronics, 166, 112443. https://doi.org/10.1016/j.bios.2020.112443
Razzino, C. A., Serafín, V., Gamella, M., Pedrero, M., Montero-Calle, A., Barderas, R., Calero, M., Lobo, A. O., Yáñez-Sedeño, P., Campuzano, S., & Pingarrón, J. M. (2020). An electrochemical immunosensor using gold nanoparticles-PAMAM-nanostructured screen-printed carbon electrodes for tau protein determination in plasma and brain tissues from Alzheimer patients. Biosensors and Bioelectronics, 163, 112238. https://doi.org/10.1016/j.bios.2020.112238
Sani, A., Cao, C., & Cui, D. (2021). Toxicity of gold nanoparticles (AuNPs): A review. Biochemistry and Biophysics Reports, 26, 100991. https://doi.org/10.1016/j.bbrep.2021.100991
Sankar, M., He, Q., Engel, R. V., Sainna, M. A., Logsdail, A. J., Roldan, A., Willock, D. J., Agarwal, N., Kiely, C. J., & Hutchings, G. J. (2020). Role of the Support in Gold-Containing Nanoparticles as Heterogeneous Catalysts. Chemical Reviews, 120(8), 3890–3938. https://doi.org/10.1021/acs.chemrev.9b00662
Sehit, E., Drzazgowska, J., Buchenau, D., Yesildag, C., Lensen, M., & Altintas, Z. (2020). Ultrasensitive nonenzymatic electrochemical glucose sensor based on gold nanoparticles and molecularly imprinted polymers. Biosensors and Bioelectronics, 165, 112432. https://doi.org/10.1016/j.bios.2020.112432
Singh, R., Kumar, S., Liu, F.-Z., Shuang, C., Zhang, B., Jha, R., & Kaushik, B. K. (2020). Etched multicore fiber sensor using copper oxide and gold nanoparticles decorated graphene oxide structure for cancer cells detection. Biosensors and Bioelectronics, 168, 112557. https://doi.org/10.1016/j.bios.2020.112557
Yang, K., Li, J., Lamy De La Chapelle, M., Huang, G., Wang, Y., Zhang, J., Xu, D., Yao, J., Yang, X., & Fu, W. (2021). A terahertz metamaterial biosensor for sensitive detection of microRNAs based on gold-nanoparticles and strand displacement amplification. Biosensors and Bioelectronics, 175, 112874. https://doi.org/10.1016/j.bios.2020.112874
You, S.-M., Luo, K., Jung, J.-Y., Jeong, K.-B., Lee, E.-S., Oh, M.-H., & Kim, Y.-R. (2020). Gold Nanoparticle-Coated Starch Magnetic Beads for the Separation, Concentration, and SERS-Based Detection of E. coli O157:H7. ACS Applied Materials & Interfaces, 12(16), 18292–18300. https://doi.org/10.1021/acsami.0c00418
Zhang, J., Mou, L., & Jiang, X. (2020). Surface chemistry of gold nanoparticles for health-related applications. Chemical Science, 11(4), 923–936. https://doi.org/10.1039/C9SC06497D
Zhang, J., Zhao, B., Liang, W., Zhou, G., Liang, Z., Wang, Y., Qu, J., Sun, Y., & Jiang, L. (2020). Three?Phase Electrolysis by Gold Nanoparticle on Hydrophobic Interface for Enhanced Electrochemical Nitrogen Reduction Reaction. Advanced Science, 7(22), 2002630. https://doi.org/10.1002/advs.202002630
Zhang, L., Mazouzi, Y., Salmain, M., Liedberg, B., & Boujday, S. (2020). Antibody-Gold Nanoparticle Bioconjugates for Biosensors: Synthesis, Characterization and Selected Applications. Biosensors and Bioelectronics, 165, 112370. https://doi.org/10.1016/j.bios.2020.112370
Zhang, Q.-P., Sun, Y., Cheng, G., Wang, Z., Ma, H., Ding, S.-Y., Tan, B., Bu, J., & Zhang, C. (2020). Highly dispersed gold nanoparticles anchoring on post-modified covalent organic framework for catalytic application. Chemical Engineering Journal, 391, 123471. https://doi.org/10.1016/j.cej.2019.123471
Zhang, X., Zhang, Y., Zhang, W., Dai, Y., & Xia, F. (2021). Gold nanoparticles-deranged double network for Janus adhesive-tough hydrogel as strain sensor. Chemical Engineering Journal, 420, 130447. https://doi.org/10.1016/j.cej.2021.130447
Zheng, J., Cheng, X., Zhang, H., Bai, X., Ai, R., Shao, L., & Wang, J. (2021). Gold Nanorods: The Most Versatile Plasmonic Nanoparticles. Chemical Reviews, 121(21), 13342–13453. https://doi.org/10.1021/acs.chemrev.1c00422
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